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KMID : 0360319940260050815
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.815 ~ p.821
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The Comparison of Blood TNF-a Level between Normal Person and Cancer Patients, and the Change of Blood TNF-a Level in Cancer Patients Receiving the Ablation Chemotherapy Regimens
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Abstract
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Tumor Necrosis Factor(TNE) is a polypeptide hormone produced in vivo by activated macrophages and lymphocytes, and they called TNF-a and TNF-βrespectively.
TNF has diverse biological effects which may provide either benefical or detrimental to the host depending on the amount of TNF produced. Blood concentration of tumor necrosis factor-a(TNF-a) were measured by enzyme-linked immunosorbent
assay(ELISA)
methods in 28 patients receiving the ablative chemotherapy regimens. And serum TNF-a level of patients with solid tumors were examined(esophageal 10, gastric 10, and lung 8) along with 27 healthy controls.
The most striking finding was spontaneous production of TNF-a in a significant proportion of cancer patients(28.72±23.74pg/ml: p<0.005) against control person.
We also found that chemotherapy increased TNF-a production with 48.4(23.69pg/ml. This increase was significant(p<0.005) compared to the prechemotherapy. Activated macrophage have been shown to exhibit cytotoxicity for neoplastic cells and are
thought to
play a significant role in tumor regression.
There is experimental evidence for its interaction with other biological agents and cytotoxic drugs. Several chemotherapy agents might increase macrophage-generated TNF-a through some mechanisms.
For-TNF-a the biological agents and importance is certain and methods designed to antagonize the release or effects of TNF-a may have clinical application
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KEYWORD
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